
AESTURA A-CICA 365 Soothing Relief Serum pH4.5: What It Is, What's Inside, and Who It's For
A fragrance-free, mildly acidic serum built around four Cica actives and Zinc PCA to calm temporary redness on sensitive skin.
The AESTURA A-CICA 365 Soothing Relief Serum pH4.5 is a lightweight, fast-absorbing serum designed to quiet temporary redness and support the skin's natural acid mantle. It suits sensitive and reactive skin types, works morning and evening, and is fragrance-free.
Who This Is For
If your skin flushes easily after cleansing, turns blotchy in cold air, or takes a long time to settle after a new product, this serum was built with you in mind. The AESTURA A-CICA 365 Soothing Relief Serum pH4.5 is formulated for sensitive skin and is listed by the brand as suitable across all skin types — including those managing reactive or easily irritated complexions.
If you are pregnant, breastfeeding, recovering from a procedure or using prescription skincare, check the brand's current guidance and ask your doctor before adding it.
One important boundary to draw: this serum is intended for temporary redness caused by external factors — environmental stress, over-exfoliation, a disrupted barrier. It is not formulated to address chronic inflammatory skin conditions, and the brand is explicit about that distinction.
What It Is and How It Feels
At its core, this is a mildly acidic serum, calibrated to pH4.5 — roughly in line with healthy skin's natural acid mantle. The idea is that a product sitting at the right pH does less work to disrupt what's already there, which matters when the barrier is fragile.
The texture is a light serum liquid that absorbs quickly and leaves a natural finish. There is no fragrance, no scent of any kind. For skin that reacts to almost everything, that absence is genuinely useful — it removes one of the most common triggers before you even get started.
The brand's proprietary complex, pH4.5CICA™, combines four types of Cica actives with Zinc PCA. This is the formulation's main character: the Cica actives are associated with calming and barrier support, while Zinc PCA is included for its role in managing surface imbalance and sebum. The pH of the serum itself is built into the complex name — a design choice, not a coincidence.
The Ingredients That Matter
The formula leads with water, glycerin, and butylene glycol — a straightforward hydration base that does its job without drama.
Niacinamide appears early in the ingredient list. It is included to support the look of even, calm skin and to help support the barrier over time.
Gluconolactone is a polyhydroxy acid (PHA) that works gently at the surface. At this pH, it contributes mild exfoliation without the sharp sting that AHAs can produce on reactive skin, making it a considered choice for a serum aimed at sensitivity.
Sodium Hyaluronate is a humectant that draws moisture into the skin and helps it feel plumped and comfortable throughout the day.
Zinc PCA is part of the pH4.5CICA™ complex. It works alongside the Cica actives to address surface imbalance, particularly useful when skin is reactive and prone to congestion as well as redness.
The formula is free from added fragrance — confirmed by the brand's fragrance-free badge.

